{"metadata":{"accession":"A0A6Q2YJ75","id":"A0A6Q2YJ75_ESOLU","source_organism":{"taxId":"8010","scientificName":"Esox lucius","fullName":"Esox lucius (Northern pike)"},"name":"Follistatin-related protein 1","description":["Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation. Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes. Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors"],"length":310,"sequence":"MMLRTLPFLVLLVLALCQAEEVQSKSKVCANVFCGAGRECAVTEKGEPSCLCIESCKPHKRSVCGSNGKTYRNHCELHRDACLTGLKIQVAHDGHCQAKKAEQVAASPVVCYVADRNELRHRVIQWLQNEVVPDGWFVKGSNFTDILLKYFKNYDNGDSQLDSSELLKFIQHNDSNVDLQSYADQESNKLLSLCVDALIELSDENADWKLSFDEFLNCLKPGFNPPEKKCALEDETYDDGSETQVECNRCVCACGNWVCTAMTCTDKTALVEETGEAGQEMTEEEWGLRVAELNKHQETVEKMKVSTKEE","proteome":"UP000265140","gene":null,"go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"74d40995f4506b494a617eb31c3cd0d8e3fda7bb","counters":{"domain_architectures":1227,"entries":24,"isoforms":0,"proteomes":1,"sets":6,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"smart":2,"pfam":4,"ssf":3,"profile":2,"cdd":2,"panther":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":1227}}}