{"metadata":{"accession":"A0A6Q2WQE5","id":"A0A6Q2WQE5_ESOLU","source_organism":{"taxId":"8010","scientificName":"Esox lucius","fullName":"Esox lucius (Northern pike)"},"name":"DDB1- and CUL4-associated factor 12 beta-propeller domain-containing protein","description":["Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus leading to their ubiquitination and degradation. Also directly recognizes the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative degron in proteins leading to their ubiquitination and degradation"],"length":483,"sequence":"MARKPVSRKRKAGESKDQQQLGWCQSAHKRTRVSSSSRHAQQWWRSRLSVVCALRGREFRPQQQHEWRLQRSLRGFAAGRLPGILKEREFSLGRLNKVFASQWLNHRQVVCGTKCNTLFVADVLTGQITRIPMLKDGHGCGTGIGGTPGASFLPGSGSVSGLDQQGCGIHAIELNPSGTLLATGGDNPNSLAVYRLPTLDPVCVGDDGHKDWIFSIAWISDSMAVSGSRDGSMGLWEVSDEILSQAMKQQDEEGVPCYSHISHRALEDIPKEYTNPYNCKVRALAFNNNHKELGAVSLDGYFHLWKAEQNLSKLLSTKLPHCKENVCLAYGQDWSVYAVGSQAHVSFLDPRQPTHSIKSVSSRERGSEATRGIRSVSFYEHIVTVGTGQGSLLFYDIRAQRFLEDPSCPASGYRQRPGEGILKLTTGKGWLNHDETWRSYFSDINSFPNAVYTHCYDDSGTKLFVAGGPLCSGLHGNYAGLWS","proteome":"UP000265140","gene":"DCAF12","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"e163c506677cb53726f73ce04eb94af0a297b973","counters":{"domain_architectures":1635,"entries":14,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"pfam":1,"ssf":1,"cathgene3d":1,"smart":1,"profile":2,"panther":1,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":1635}}}