{"metadata":{"accession":"A0A6P9DNA7","id":"A0A6P9DNA7_PANGU","source_organism":{"taxId":"94885","scientificName":"Pantherophis guttatus","fullName":"Pantherophis guttatus (Corn snake)"},"name":"Phosphatidylethanolamine N-methyltransferase","description":["Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step"],"length":219,"sequence":"MPLPLDCCGGLNNVDYSKVDLSAMTLLSDYVNVTDPNFIVAVISIAFNPLFWNVVARWEHRTRSLTRIFGSPYVACYFLGVVIILLNFLRTHCFGEAMKSQPKLPLLDCLLGYYASVTLIAVGILLVTSSFLALGFIGTFLGDYFGILMETKVTSFPFNVTENPMYWGSTSIYFGWSLMNASPVGLVLTVVVTLCYAVALLYEGPFTEEIYRNKAPKSK","proteome":"UP001652622","gene":"PEMT","go_terms":[{"identifier":"GO:0008757","name":"S-adenosylmethionine-dependent methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006656","name":"phosphatidylcholine biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"1d9a6873267fbe30f852dd2ebe128eea30ccf9df","counters":{"domain_architectures":18289,"entries":8,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cathgene3d":1,"panther":1,"pirsf":1,"hamap":1,"pfam":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":18289}}}