{"metadata":{"accession":"A0A6P8TQ69","id":"A0A6P8TQ69_GYMAC","source_organism":{"taxId":"8218","scientificName":"Gymnodraco acuticeps","fullName":"Gymnodraco acuticeps (Antarctic dragonfish)"},"name":"Atypical kinase COQ8A, mitochondrial","description":["Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3. According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. However, the small molecule kinase activity was not confirmed by another publication. Shows an unusual selectivity for binding ADP over ATP"],"length":647,"sequence":"MAGDMILVMRGLAKLSQAVVETQSSTLRSGAGVAAAVQSVQSAAEQSLSAAMMKMQEMTGQQQTSSTESEFDFPQDDSAFAEFKDEGVDFTVAHQGMSEDIAAAGESHVRGKQSLFDGYKDPSKQFSGHTRSYHQDIRHFYSHGLNRHVWGQLYRQHQLRSYHQDPSTVGGLTAEDIEKARQGKKVEIKSHKQMLSERARERKVPVSRLSRLANFGGLAVGLGIGALAEVAKKGMRQNTEGDKKRVLDSSPFLSEANAERIVRTLCKVRGAALKVGQMLSIQDDAFINPQLAKIFDRVRQSADFMPIKQMTKALNGDLGPNWRDKLESFEERPFAAASIGQVHLARMKDGREVAMKIQYPGVAQSINSDVNNLMTVLNISNALPEGLFPEHLIDVMRRELALECDYIREAQCAKKFREFLKDQPFFYVPEVIDELSSAHVLTTELVPGFPLDQADGLTQDLKNEICENILKLCLRELFEFRYMQTDPNWSNFFYDPQTHRVALLDFGATRGFDKSFTDPYIEVIRSAAEGDREGVAKKSIEMKFLTGYESKAMINAHVDAVMILGEAFNSTDTFEFGAQSTTERIHNLIPVMLKHRLTPPPEETYSLHRKMGGSFLICARLNAKLNCKDMFQNTYAKYWEGRTPPAR","proteome":"UP000515161","gene":"coq8aa","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"dc1877394c38eec4c95cc07286a0b8fbdffcae18","counters":{"domain_architectures":38771,"entries":8,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"pfam":1,"ssf":1,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":38771}}}