{"metadata":{"accession":"A0A6P8SCJ6","id":"A0A6P8SCJ6_GEOSA","source_organism":{"taxId":"260995","scientificName":"Geotrypetes seraphini","fullName":"Geotrypetes seraphini (Gaboon caecilian)"},"name":"E2 ubiquitin-conjugating enzyme","description":["Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination"],"length":210,"sequence":"MNSNVENLPPHIIRLVYKEVSTLTSDPPEGIKIFPNEEDITDLQVTIEGPEGTPYAGGIFRMKLILGKDFPAMPPKGYFLTKIFHPNVGSNGEICVNVLKKDWKAELGIRHVLLTIKCLLIHPNPESALNEEAGRLLLENYEEYAARARLLTEIHAQVCSLRAKDQAATADPCSSSATGDGPMAKKHAGDRDKKLAAKKKTDKKRALRRL","proteome":"UP000515159","gene":"UBE2S","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"96b2a7d582dea26386e8f982d2fd40014d2b06f9","counters":{"domain_architectures":122920,"entries":12,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"profile":1,"smart":1,"pfam":1,"panther":1,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":122920}}}