{"metadata":{"accession":"A0A6P8QDV3","id":"A0A6P8QDV3_GEOSA","source_organism":{"taxId":"260995","scientificName":"Geotrypetes seraphini","fullName":"Geotrypetes seraphini (Gaboon caecilian)"},"name":"Phosphodiesterase","description":["Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP"],"length":843,"sequence":"MACGRNFANSSNISLICSELREMVNAWFAERVHAIPTSKEGGKECQTEPCGNQQPARPETPTRKISASEFDRPLRPIVVKDSEGAVSFLPDSERRTQMPPQPPRFSSSTSDRCTRLLELVKDISSHLDVAALCHKIFLHINELIAADRYSLFLVCEDSSNEKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAALGQALNIKDAYKDPRFNAEVDHITGYKTQSILCMPIKNQREEVVGVAQAINKKSESGGTFTEQDEKDFAAYLAFCGIVLHNAQLYETSLLENRRNQVLLDLASLIFEEQQSLEVILRKITATIISFMQVQRCTIFIVDEDCPNSFSSVLHTESKDVEESAMAIKRRDHDMNSLNYMYAQYVANTMEPLNIPDVWKDRRFPWTNEKAENKRPNVQSLLCTPIKNGKKNKVIGVCQLENKIEEKSGKIKSFNRNDEQFLEAFAIFCGLGIQNTQMYEVVERAMAKQMVTLEVLSYHASATEEDTRELQVTAASVVPSAQSLKLMDFCFNDLELSDPETILATIRMFTDLGLLQNFQIKYEVLCRWILSVKKNYRTNVVYHNWRHAFNTAQCMFAALRTGKIQSKLSALEILALLIAALSHDLDHRGVNNSYIQRSDHPLAQLYGHSIMENHHFDQCLMILTSPGNQILSGLSLQEYKCALKVIKQAILSTDLALYMKRRGEFFDLVRRNAFRWENTEHKELFVAMLMTACDLSAVTKPWPVQQRVAELVASEFYEQGDKERIELHIEPIDLMNREKKDKIPSMQVGFIDAICLQLYEALTQVSEACCPLLDGCRKNKERWQVLSEQQEKNRTNGENQTPVKLNAEQ","proteome":"UP000515159","gene":"PDE5A","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004114","name":"3',5'-cyclic-nucleotide phosphodiesterase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008081","name":"phosphoric diester hydrolase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"96e7541143598daee1067ec7e4cbcca3b18ee887","counters":{"domain_architectures":8952,"entries":20,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"smart":2,"pfam":2,"profile":1,"cdd":1,"panther":1,"prints":1,"prosite":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":8952}}}