{"metadata":{"accession":"A0A6P8ND42","id":"A0A6P8ND42_GEOSA","source_organism":{"taxId":"260995","scientificName":"Geotrypetes seraphini","fullName":"Geotrypetes seraphini (Gaboon caecilian)"},"name":"Rho guanine nucleotide exchange factor 12","description":["May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13"],"length":1466,"sequence":"MTGRDSTSRKTKSSWDESRHETYGLVQRCVIIQRDENGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPHIPLAENEGDSVTFVQNLSPVATSPRSPGASGNVERITSPVLMGEENNIVHNQKVEILRKMLQKEQEQQQSLLEEYSQASSTRLLKEIQESKKHLHQLQVQLCKATGLSQDDILLLKLPSEVLRISELEAESGDGLGKTDLSSGDTSRPDNEIADSPQSGLKEKSHLDESLEKSELQDTDLQLGVGIPTVRLGNHIIGAEDDDFDAEQEQINGQCNCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYADLYKQTNSKETRRVFLEFNQLFLDRAANLKVLVPDDVALDLEKRRPELIPEELHRHYIQTMQEKVYLDVHRHLEDFRQKRSMGLTLAEAELARLDAERVRDQTTLEKERQSAEHIISKIEEVLMTSQPLEEEKSSTMQYVILTYMKHLGVKVKEPRNLEQKRGRIGLLPKIKQSIKKEKENDEKVKRRVFPSILVPPRRPSRHDSSAIGRAMEMNKQRHPKHLSTSSSSPEPADLGKMRQSESSDFNPISPPNSGIYSSPEGSKDEIGLKQTEVLSSSDSCDSTPRTSGTMFDFPSPPLEHLHEDEREFERLADLGTPKLFRKLDSVGFGDIQSEDELYDFDVETDPPSWQQLVGREVLRGLKPHEIKQQEVIHELFYTERAHVRKLTVLDQVFYQRISREGILPISDIRSIFSNLDEILMLHVGLNEQMRSVRKRNETSVIDQIGEDLLTWFNVEGEEKLKQATAIFCSNQSFALEMIKSRQKKDSRFLSFMQDAESNPLCRRLQLKDIIPTEMQRLTKYPLLLDNIAKYSDRPEEKEKVKKAADCCRQILNHVNQAVKEAENKQRLEDYQRRLDLSYLKQAEDPMLDEFRNLDLTKRKMVHEGPLTWKVNRDKTIDLYTLLLEDILVLLQKQDDKLVLRCHSKILASSADSRHIFSPIIKLNTVLVRQVATDNKALFVISMSENGAQIYELVAQTVSEKNMWQDLIAQMAGTDKVVTKRVIPLPQVDEQEEEDQQKLKDELQDIPSYGLQSSDKDLDMDSHMVMKSLSPSPTTSEKPEVADLEQEAWSQSSFEQEQQTLDALKEGELPHSISQQQWAIDALRNLSALRHLLVQHLGLPEGGARKDWQLLPACRTLFHRPYIDSALKHLNNSVQNQQETDRIPPTTKEPAASFGVQTLSEGMKLQTGGPKRSSCSKDPPTGSLETPTVDLDSGAEEGGDQFFDARDAYSDDNPSESEGTDRKDEEVTLLRISGNYLILDGYEMLQESSTDDELSSSVTQCTTSSPLTDCFLQNLDLPGNIQDDAGIAPSAVELLGQHSQMGAEGPWSSPKIIPFTSASSSQILQYIQTIETDLEHLKGIEDSYHTLCQRMAGSALLDEASDKS","proteome":"UP000515159","gene":"ARHGEF12","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005085","name":"guanyl-nucleotide exchange factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0035556","name":"intracellular signal transduction","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"0f1589defe441b3f51f1b9ea9ad7b5a774e964ea","counters":{"domain_architectures":2825,"entries":33,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"ssf":4,"cdd":2,"profile":3,"pfam":4,"smart":3,"panther":1,"prosite":1,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":2825}}}