{"metadata":{"accession":"A0A6P7YLU9","id":"A0A6P7YLU9_9AMPH","source_organism":{"taxId":"1415580","scientificName":"Microcaecilia unicolor","fullName":"Microcaecilia unicolor"},"name":"PRKCA-binding protein","description":["Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function"],"length":398,"sequence":"MFADPDFDIEEDKLGIPTVPGTVTLKKDTQNLIGISIGGGAQYCPCLYIVQVFDNTPAAIDGTLAAGDEITGVNGKSVKGKTKVEVAKMIQNVKAEVTIHYNKLQADPKQGKSLDIVLKKVKHRLVENMSSGTADALGLSRAILCNDGLVKRLEELERTAELYKGMMEHTKRLLRSFYELSQTHRGFGDVFSVIGVREPQPAASEAFVKFADAHRSIEKFGIRLLKTIKPMLNDLNTYLNKAIPDTKLTIRKYLDVKFEYLSYCLKVKEMDDEEYSCIALGEPLYRVSTGNYEYRLILRCRQEARSRFAKMRKDVLEKVELLDQKHVQDIVFQLQRFVSTMSKYYDDCYAVLKDADVFPIEVDLARTTLSYGQKDIFTEGAEEEEDVEENEEKLIDDA","proteome":"UP000515156","gene":"PICK1","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019904","name":"protein domain specific binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"61e91bb4dcfbaa5c15d4460ae7510ed875005d57","counters":{"domain_architectures":1960,"entries":19,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"cdd":2,"pfam":2,"profile":2,"smart":2,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":1960}}}