{"metadata":{"accession":"A0A6P7I6P7","id":"A0A6P7I6P7_9TELE","source_organism":{"taxId":"210632","scientificName":"Parambassis ranga","fullName":"Parambassis ranga (Indian glassy fish)"},"name":"Endonuclease V","description":["Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures"],"length":256,"sequence":"MSAPPAEDLLEEWKSEQERLRQQVVEVDTEDWQRKPDFSGLQRVGGMDLSFIKGDDFNACAQLVVLSYPDLKLLYEDSQMVTLTAPYVAGFLAFRETPFLLEALQRLRMKQPNLLPQVVFVDGNGLFHYREFGLACHLGVLSGLPCVGVAKNLLQVQGVHKSEEHQAQIAALQKGGDSFPLTAASGKVLGKALRSSDSSSKPVYVSVGHRISLDTAVRLTHSCCRYRVPEPIRQADCRSREYLRKHFPAADACTKE","proteome":"UP000515145","gene":"endov","go_terms":[{"identifier":"GO:0004519","name":"endonuclease activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"b5a39602cf38e8ce3ece3fd23a0477f612e3b1c6","counters":{"domain_architectures":9514,"entries":6,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"pfam":1,"panther":1,"hamap":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":9514}}}