{"metadata":{"accession":"A0A6P7HS51","id":"A0A6P7HS51_9TELE","source_organism":{"taxId":"210632","scientificName":"Parambassis ranga","fullName":"Parambassis ranga (Indian glassy fish)"},"name":"BTB domain-containing protein","description":["Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting nfe2l2/nrf2 nuclear accumulation and expression of phase II detoxifying enzymes"],"length":602,"sequence":"MQCPMRKKRPTRDSDFSAIVVPSMHGSGYLDYTVETHASRSLKVMDEFRRQEMLCDLVLHVTYKERTMDFKVHKVVLASCSPYFRAMFTNNFKECHASEVTLRDVCPQVVGRLIDFAYTSHITVGEKCVLHLLLAAMRYQVEDVAKACCDFLIKHLEPANVIGIARFAEEIGCTELHQQSREYINMHFNEVTKEDEFFSLSHCQLLELISQDSLKVLCESEVYKACTDWVRWDMEGRAQYLHALLNAVHIYALPPKFLKNQLLSCPILSKANSCKDFLSKIFQDMTLRKLPPAPNRGTQLIYVAGGYRQHSLASMEAYDPRRNVWLKLADMGAPCSGLGACALFGLLYTVGGRNLSLQNNTESNTLCCYNPMTNQWSQRASLNIPRNRVGVGVVDGCIYAVGGSQGSIHHNTVERWDPESNRWSFVCPMSVARLGAGVAACGGALYVVGGYDGQNRWNTAEKYQPDTNTWQQLAPMNTIRSGMGLVCVNSYLYAIGGYDGRSQLCSVERYNIARNFWETRAPMQYSRSAHGATVHQGRIYVLGGFNQHGFLSSVECYCPDRNEWMCVTDMPVGRSGMGVAVTMEPCPGSLPDQEEEDEEGAT","proteome":"UP000515145","gene":"LOC114427559","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4b37c4a325da8293423092f75d95e59d23fc139e","counters":{"domain_architectures":3583,"entries":20,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":2,"pfam":3,"profile":1,"smart":3,"pirsf":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":3583}}}