{"metadata":{"accession":"A0A6P6IN67","id":"A0A6P6IN67_PUMCO","source_organism":{"taxId":"9696","scientificName":"Puma concolor","fullName":"Puma concolor (Mountain lion)"},"name":"C-X-C chemokine receptor type 3","description":["Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response. Binds to CCL21. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling"],"length":593,"sequence":"MGPAVALGQPGANCLPAPGNVRHSRGSSRVLHVQASSLPLLQPGGRTALGWNVASFHASSPAREAVVVGLESLGPHAASSCYLPNTWADASLSTSSSTSTSATTTSRQPFSEQWAGAFGTGTPGDILRIYERGCEAADAERKGEEMAPFPVCGWVPPQQRSQGNGPGVPVASVLGRSGIDKPMEEAAANNHVKPSLPPCSADRNWGLPDRGATPGNAQRSPLPPSLPLQMSEHQVFDASELAFLLENCSSSYDYAENESDSCCASPPCPQDFSLNFDRAFLPALYSLLFVLGLLGNGAVAAVLLSQRAALSSTDTFLLHLAVADALLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLSIVHATQLYRRGPTARVALTCVVVWGLCLFFAIPDFVFLSARRDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYARILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVMVDTLMDLEALSRNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLTRLGRPDLRGHQRQPASFRRDSSWSETTEASYSGL","proteome":"UP000515131","gene":"CXCR3","go_terms":[{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016494","name":"C-X-C chemokine receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0002685","name":"regulation of leukocyte migration","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006935","name":"chemotaxis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006954","name":"inflammatory response","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004950","name":"chemokine receptor activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"587fa3dbe4504dc051049f3cca904dd9ab631b87","counters":{"domain_architectures":394800,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"cdd":1,"profile":1,"pfam":1,"panther":1,"prosite":1,"prints":3,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":394800}}}