{"metadata":{"accession":"A0A6P6HM24","id":"A0A6P6HM24_PUMCO","source_organism":{"taxId":"9696","scientificName":"Puma concolor","fullName":"Puma concolor (Mountain lion)"},"name":"Receptor-type tyrosine-protein phosphatase C","description":["Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity"],"length":1185,"sequence":"MTMYLWLKLLAFGFAFLDTGVFVTGEDNTLSSPGVTQPPTFPTHADSQAPSAGSDTQTPSSTATPPALTPAPGKNDTSDQSLTSTPPATSIMTASETVPTTPKQSCDEKYKVISVKYRYDYGNNSFIAKLNVSDDVKCENAICKMNEIHNLPACENKNVTISHTSCDPPNKIIELDVPPDPESFYLKTCTEPTKANISICLRLEKKENFTCDEKKITHVLNCANFSSSNKTETYLEPLSPKQNYSCNLKVLYGANVFLNKNETFETDVGSPKAPPNITCKPISSTEGRITWESPEDYFDNYVLCLPHASENCIVLDKEETERNLQNLKPYTKYSVSLKASTMGKVQRDGPAVTCEFETLADKPTKVRHLLASRISDNSILVKCDPPSDFKGPNNGSYHLEVKTGDAFVKNESQIFCHFSVLYLQYSTKYEFKVYYNNGHHNGTPESVFHSTSYNSKALIAFLVFLIIVTFLALLFVLYKIYDLRNRRSSDIDEQQELVERDDEKQLMSVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFSIKDARKPFNQNKNRYVDILPYDYNRVELSDINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRTFGDVVVKITEHKRCPDYIIQKLNITNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVSLSELHPYLPNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEQNKSKNRNSNIIPYDFNRVPLKHELEMSKESEHDSDESSDDDSDSEETSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTGLKNGDQEVCAQYWGEGKQTYGDIQVDMKDTNQSSAYTLRVFELRHSKRKDFRTVYQYQYNNWNVDELPPEPKELISMIQILKEKLPKKNSTEGTKHHKNVPLLIHCGDGSQQTGLFCALLNLLESAETEEVIDVFQVVKSLRRARPGMVPTFEQYQFLYDIVASAYPAQNGQIKKSNNQEDKIQFDNELDKAKQDANCVSSPDALDNANEGNKEDEGAKVTSSPEEPEHSANGPASPGLTQSA","proteome":"UP000515131","gene":"PTPRC","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004725","name":"protein tyrosine phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006470","name":"protein dephosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016311","name":"dephosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0050852","name":"T cell receptor signaling pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"85844d6eb9bd8dc5b73af3411b09ae3aeaea3b61","counters":{"domain_architectures":126,"entries":31,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"smart":3,"cdd":3,"pfam":4,"profile":3,"panther":1,"prints":1,"prosite":1,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":126}}}