{"metadata":{"accession":"A0A6P6ERS5","id":"A0A6P6ERS5_OCTDE","source_organism":{"taxId":"10160","scientificName":"Octodon degus","fullName":"Octodon degus (Degu)"},"name":"24-hydroxycholesterol 7-alpha-hydroxylase","description":["A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)"],"length":476,"sequence":"MSEDLHPGVAALAALLAGVALLLVLRRRGSRRPPCTAGWIPWVGAGLRFGKAPLEFIEQARAQYGPVFTIFAMGKRMTFVTEEEGINVFLKSKEVNFELAVQNPVYHTASIPKNVFLTLHEKLYITMKGKMGAFNVYRFAEQLNEEFHERLEDLGPHGTMDLISLVRHLLYPVTVNVLFKKALFLSYKKKTEDFCQHFQIYDEGFECGSQMPEWLLRNWSKSKRWLLALFEESIPDIKAYKPERADSMTLMQAVLDVVEGVAAGHSASCALLMLWASLSNAVPVTFWTLAFILSHADIHKTIVEGISSVLGGAGKEKIRVTQDTLKKLSLIKWCILEAIRLRAPGVITRKVVKPVKILNYTVPSGDLLMLSPFWLHRNPQYFPDPESFKPERWKEADLEKHAFLEHYMAFGGGKFQCPGRWFALLEIQICIILILYKYDCSLLDPFPMQRFYWEQKIETCAHPYLEAHPGRGERSR","proteome":"UP000515203","gene":"LOC101592465","go_terms":[{"identifier":"GO:0004497","name":"monooxygenase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005506","name":"iron ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016705","name":"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0020037","name":"heme binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a02e61ba6c64bb9a9c779746e03a6c43264a16fb","counters":{"domain_architectures":520850,"entries":11,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"panther":1,"pirsf":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":520850}}}