{"metadata":{"accession":"A0A6P6EJN7","id":"A0A6P6EJN7_OCTDE","source_organism":{"taxId":"10160","scientificName":"Octodon degus","fullName":"Octodon degus (Degu)"},"name":"3'-5' RNA helicase YTHDC2","description":["3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis"],"length":1434,"sequence":"MSRPSSVSPRPPAAGGGVGGGGGGSVACGSGGGRRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTSGRLNNGIPQIPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIHIQGRPFEVKEMFLEDILRSTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQDNTFKPESQRQRTVPNVTEEYDLLDDGGDAVFSQLSEKDVNCLEPWLIKEMDTCLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTDGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDTGAVLIFLPGYDEIVGLRDRILFDDKRFADSTHRYQVFMLHSNMQTSDQKKVLKTPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAVQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPINCTIADFLMKAPEPPPTLIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLSAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENVVLTGPKEKKVRFHPTSVLSQPQYKKIPPANGQVAAIQALPTDWLIYDEMTRAYRIANIRCCSAVTPVTVVVFCGPSRLASNALQEPSSFRADGIPNDSSDSEMEDRTTANLAALKLDEWLNFKLEPEAANLLLQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWKANNSRKSAADCEFSDESTTAERVLMKSPSAALHPPQKYKDRGILHPKRSTDDRSDQSSVKSTDSSSYPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRNLEISQQKGIWSTTPSNERKLNRAFWESSMVYLVFSVQGSGHFQGFSRMSSEIGREKSQEWGSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPQNSPVEDIMPITTIECTDFKKLI","proteome":"UP000515203","gene":"Ythdc2","go_terms":[{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"ida_accession":"972484cd8d8f5dd28519713c3977f75af841ea07","counters":{"domain_architectures":436,"entries":45,"isoforms":0,"proteomes":1,"sets":9,"structures":0,"taxa":1,"dbEntries":{"profile":6,"smart":4,"cathgene3d":5,"cdd":4,"ssf":3,"pfam":8,"panther":1,"interpro":14},"proteome":1,"taxonomy":1,"similar_proteins":436}}}