{"metadata":{"accession":"A0A6P6E8Q0","id":"A0A6P6E8Q0_OCTDE","source_organism":{"taxId":"10160","scientificName":"Octodon degus","fullName":"Octodon degus (Degu)"},"name":"Protein zwilch","description":["Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex"],"length":562,"sequence":"MWARTNRATEEFYARLLQEFNEEKKGVYKEPFIYEADVQVQLISKGQPNPVKGLLGENDLVFIVEKVPLEKEETSHVEELQSEETAISDFSSGENVGPLPLPVGRARQLIGLYTMAHNPNMTHLQVPRPIAALPPLWVRCDGSDPEGTCWLGAELVPEGDGIAGVVLFAVSCKGSACALFQVTARGFAQYELFKSSVLDDTVSPSHTAITLDISWSPVDEMLQVPPLSSAATLNIKVESGAPRGCLTHLHRELKFLLVLTDGLRTGVTEWLEPLEAKSAVELVQEFLNESSKLDGFGDSTKKDPETVKHDAAAVDRSVLITVRGDLDFVEQLWCRMSSSVVSYQDLVKCLALILQSLQRGDIQPWLHSGSSSLLSKLIHQSYHGTMDTVSLSGTLPLQMLLEIGLDKLKKDYISFFIGQELASLNHLEYFTSPSVEIQEQVHRVQKLHHILEVVVSCMLFVKPQHEFLFSLTQSCIKYYKQNPLDEQHIFQLPVRPACVKNFFQSEKPQKWKVEINGGQKKVKTIWQLSDSSPVEHLMHHKPALSGCIEKSAGVLKVDLMVF","proteome":"UP000515203","gene":"Zwilch","go_terms":[{"identifier":"GO:0007093","name":"mitotic cell cycle checkpoint signaling","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:1990423","name":"RZZ complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7e8dc56355427df32da3f919291fc4bfff0ed7b9","counters":{"domain_architectures":1571,"entries":8,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":5,"panther":1,"pfam":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":1571}}}