{"metadata":{"accession":"A0A6P5QUR1","id":"A0A6P5QUR1_MUSCR","source_organism":{"taxId":"10089","scientificName":"Mus caroli","fullName":"Mus caroli (Ryukyu mouse)"},"name":"tRNA(His) guanylyltransferase","description":["Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress"],"length":298,"sequence":"MWAFRTARIGSLLAATSVILRRCLRLGVAMAKSKFEYVRNFEVQDTCLPHCWVVVRLDGRNFHRFAEEHNFAKPNDSRALHLMTKCAQTVMEELEDIVIAYGQSDEYSFVFRKKSNWFKRRASKFMTLVASQFASSYVFYWRDYFEDQPLRYPPGFDGRVVLYPSNQTLKDYLSWRQADCHINNLYNTVFWALIQQSGLTPVQAQQRLKGTLTADKNEILFSEFHINYNNEPHMYRKGTVLVWQKVEEVRTQEVRLPAEMEGEKKAVARTRTRVVALNCDLIGDAFWKEHPEILAEEN","proteome":"UP000515126","gene":"Thg1l","go_terms":[{"identifier":"GO:0000287","name":"magnesium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008193","name":"tRNA guanylyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006400","name":"tRNA modification","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"b509ab2e6bff8d8efab83978307f20afe9e8f813","counters":{"domain_architectures":3975,"entries":9,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pfam":2,"pirsf":1,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":3975}}}