{"metadata":{"accession":"A0A6P5LRV8","id":"A0A6P5LRV8_PHACI","source_organism":{"taxId":"38626","scientificName":"Phascolarctos cinereus","fullName":"Phascolarctos cinereus (Koala)"},"name":"Translation initiation factor eIF2B subunit epsilon","description":["Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed"],"length":718,"sequence":"MAATAAASRGGKRAGGTGGQGGGAAGRGAEEEAPPPLQAVLVADSFNRRFFPISKDRPRALLPLANVALIDYTLEFLTATGVQETFVFCCWKAPEIKEHIHKSKWCLPTSPNVVRIVTSETYRSLGDVLRDVDAKALVRSDFLLVYGDVISNINISHALEEHRSRRKREKNVSVMTMIFKESSPSHPTRCPEDNVVVAVDSTTHRVLHYQKTHGLRRFSFPLSLFRGSGEGVDIRYDLLDCHISICSPQVAELFTDNFDYQTRDDFVRGLLVNEEVLGNHIHMHVTTREYGARVSNLRMYEAVCADVVRRWVYPLTPEMNFTDSPAQSCTHSRHNIYRGLEVSLGHGSVLEENVLLGAGTVIGSNCTIKNSVIGPDCHIGDNVLLDQAYLWQGVRVASGAQIRQSLLCDHSEVKERVILKPRCVLTSQVVVGPDLELPEGSVISLHPPDEEEEDDDSQFSDDSGADRTERVKSTGYSPSDVGAAGQGYLWRAQGANPGEEEDEEELRQSLWGLTINMDEESESDSEQSLGSQELDSRAGSPQLDDIRVFQNEVAGTLQRGQEENISCDNLVLEINSLKYAYNISLKEVMQVLSQVVLEFPLEQLNSQLDPNCYCGLLLPLLRAWSPVFKNYIKRTGDHLQALTAIEEFFLEHDSLVTSLAKVLMTFYELDILAEETILQWFHQKDVPDKGKQLRKNQRLQNFIQWLKEAEEESSDEQD","proteome":"UP000515140","gene":"EIF2B5","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005085","name":"guanyl-nucleotide exchange factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0031369","name":"translation initiation factor binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009058","name":"biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"07bf0236dc6e7930a4a95a7ed51d9e566657e9b4","counters":{"domain_architectures":2427,"entries":24,"isoforms":0,"proteomes":1,"sets":6,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":3,"cdd":3,"pfam":3,"profile":1,"smart":1,"panther":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":2427}}}