{"metadata":{"accession":"A0A6P5JID4","id":"A0A6P5JID4_PHACI","source_organism":{"taxId":"38626","scientificName":"Phascolarctos cinereus","fullName":"Phascolarctos cinereus (Koala)"},"name":"Mitotic spindle assembly checkpoint protein MAD1","description":["Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling"],"length":707,"sequence":"MENLEEENTAVLSCLRTLENFLSKPDVEEGSNLNVQYQQSMQLEERAEQIRSKSHLIQVEREKIQMELSHKRARVELEKAATANARNYEREADRNQELMTRIKQLQEREVEAENKLKEQIEINRSRKQDLDTANKKLQEKENKLAEANQTINELKGKISELQWNIMNQEMQVKNLESQKQELMEQLDVQHKKWQEASQRVLELQESQCLIADSEKKIKELEQKLSLQEQDAAIVKNMKSELVRFPKMEREVRQLREENVYLREMKENNGLLKEEVEGLQRKLERHEKLQEDMVALELEKEKLLERLKSWEGLEQTMGLNIRTPEDLSNYILSLQQKEIELAEKSTASTSSARILEKMRQQLLEDLLKVQSELLEERKKREYNEDLVRRLQKRVFLLTKERDVMRSILDSFENDMSPLENSPQLALQVHEDMVQNLQANCAEMEVQLSQTLEELGNQKERAEMLDIELKILKSQTGTVDQSFFVSSDELNALRLKVEELVMERSQLEDDKKNLEMQLEKLTLQGHYDQSKTKVLHLSMNPTSLAKERLKMEQQQLQEECQQLQELVRVLEGGGSITNKSEVAGCLQPSQEISDLKKKLESSELRNQRLKEVFQTKIQEFRKVCYTLTGYRIDLTTENQYRLTSMYAEHKSDCLIFKASNPSRTKMQLLETEFSHTVRELIDLHLLQQDSIPVFLSSVTLDLFSRQTIT","proteome":"UP000515140","gene":"MAD1L1","go_terms":[{"identifier":"GO:0007094","name":"mitotic spindle assembly checkpoint signaling","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"622eb6721730d4ccc66a7951384dba51a5f2777c","counters":{"domain_architectures":4333,"entries":7,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":1,"panther":1,"pfam":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":4333}}}