{"metadata":{"accession":"A0A6P5IR86","id":"A0A6P5IR86_PHACI","source_organism":{"taxId":"38626","scientificName":"Phascolarctos cinereus","fullName":"Phascolarctos cinereus (Koala)"},"name":"Dynein axonemal heavy chain 12","description":["Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly"],"length":3728,"sequence":"MSDDEDKEDKDVIAAEKEALNLKLPPIMYPPEEIGADTPLQSKLLKFRRVKEQGKRLNQIITVGAIKKHMRISEEKKKRSPIAPEPEYPSTMYSDLRRRGENYIFMKKRVESHPIVPIQREWLDNMLKLVPQSLKNGREREQLVENLLNEVTTEFERSMKRYLVRTVLVRPPVSWLEDEGGPLPESPLGLDYSKPWHSNYVQARSQVSENLHVLHPTLRTLLDLGYTTFANRLLLDLTGFRAKGPMDCESLRNDVSINARKTEEKLMNTWYPKVINIFTKKEAHDDIKAEKLDSFYNCVSTLMSNQLRDLLKRTVEGFVNLFDPNDNKWLPIFKMELTFDDEKMDFYPTFQDLQEVVGGVVDWIGETLKNVQTVQSWLAGGPTTVKLNTDLPDHMLDQAFRTLREAVNLNLQGPKEHFNEYVEKYSWLINGTAVDQIQTFQAEDHTFDEYTERIEYFLNLAKEIMMLPNLAHFPMILLDCDDLKEGLVNKVKGYANLLLNDIATKHRNENESICIEFENIKEHALKVPETTEEMMELISYVENARTKGVQELALRIQECQRRTNYLLDVFMFPPEDLDLNASVLLWPRNMNPIFNENDELIENAKRKGETDLVTKREKLILEIEKETRRMGEFTEYAELEWMQQYVMDVRLLQKRIQEAEDMVAFINKEEGLFKWELTKYPELDKLKVSVEPYQKFFSFILKWQRTEKRWMDGGFLDLNGESMETDVDEFFREIYKSLRFFQLKQKKEAQEKRKAAGKRSIIDEKIEEDIQDNPTVVMCSAVMEQIKAFKEYIPTVTILCNPGLRARHWKEMSEIVGYDLTPDSGTTLRKVLKLNLDPYLEKFEVISAGASKEFSLEKAMHTMINTWDDIAFHISPYRDTGVSILSAVDEIQTILDDQIVKTQTMRGSPFIKPFEEEIKAWEDRLIRIQETIDEWLKVQAQWLYLEPIFCSEDIMQQMPEEGRQFQMVDRHWRDVMKYCAKDPKVLAATSLTGLLDKLQNCNDLLDKIMKGLNAYLEKKRLFFPRFFFLSNDEMLEILSETKDPLRVQPHLKKCFEGIAKLEFLPNLDIRAMYSTEGERVELISLISTAEARGAVEKWLIQVEDLMLKSIHQVIALSRMAYPQSERKDWVQEWPGQVVLCVSQMYWTIQTQESISSEPEGLKSYYNHLQLQLNDIVGLVRGKLSKQTRITLGALVTIDVHARDVVMDMIEMGVSTNTDFQWLAQLRYYWEWENVRVRIINCNVKYAYEYLGNSPRLVITPLTDRCYRTLIGAFYLNLGGAPEGPAGTGKTETTKDLAKALAVQCVVFNCSDGLDYLAMGKFFKGLASSGAWACFDEFNRIELEVLSVVAQQILCIQRAIQLKLEVFNFEGTELKLNPNCFVAITMNPGYAGRSELPDNLKVLFRTVAMMVPNYALIAEISLYSYGFLNAKLLSVKIVMTYRLCSEQLSSQFHYDYGMRAVKAVLVAAGNLKLKFPNENEDILLLRSIRDVNEPKFLSHDIPLFNGITSDLFPSVKLPEADYNDFLECAHECCKAHNLQPVKVFLDKMIQTYEMMIVRHGFMLVGEPYAGKTKVLHVLADTLTLMNERSYGEEEKVIHRTVNPKSITMGQLFGQFDPVSHEWTDGIVANTFREFALSETPDRKWVVFDGPIDTLWIESMNTVLDDNKKLCLMSGEIIQMSAQMSLIFEAMDLSQASPATVSRCGMIYMEPLQLGWEPLVTSWLHTLKEPLDRKEYQELLQELFDWLIPSALRVRQKKCKELIPTSNSNVVISLTRLFEVLLCKVAAEDPNGKHIRVWIMACFIFSLIWSIGGTCDTDGRLVFDSFIREIITGKNEEHPIPPGVGKWECNFDERGLVYDYTYEMKNRGRWIHWNELIRTTSLGEKKAKIQEIIVPTMDTIRYTFLMDLCLTYEKPLLFVGPTGTGKSVYVKNKLMHHLNRDQYFPFFVNFSARTSANQVQNIIMARLDKRRKGVFGPPMGKKCVIFIDDMNMPALEKYGAQPPIELLRQFFDYGNWYDLKDTTKILLVDTQLIAAMGPPGGGRNPVTPRFIRHFNICSINTFSDETMVRIFSAIVAFYLRTREFLPEYFAVGNQIVSGTMEIYKRSMENLLPTPAKSHYTFNLRDFSRVILGCLLINKEVVESKHTMVRLFVHEVLRVFYDRLVDDYDRAWLFQLIKVVIKDHFKENFDTVFSHLRKGNAPVKEEDLRSLLFGDYMNPDLEGDERIYTEIPNVKHFSDVVEQCLEEYNQTHKTRMHLVIFRYVLEHLSRICRILKQSGGNALLVGLGGSGRQSMTRLATSMAKMHLFQPEISKSYGMNEWRDDLKNLLRSAGMKGLKTVFLITDTQIKEEAFLEDVDSVLNTGEVPNIFAADEKQEVMEGVRPAAQAGIKHGELSPLALFAFFVNQCRDNLHVVVAFSPIGDAFRNRLRQFPSLINCCTIDWFQPWPDDALERVAVKFLETLELTKNERLEVVPICKHFHTSIMDLSARFLQDLGRHNYVTPTSYLELIAAFRQLLTQKRQAVMKSKFRYTNGLDKLDFAESQVGEMKLELVQLQPRLEEAKVENANMMKVIEAESAQVEAKSRFVKIDEELATGKAEEAQALKNECESDLAEAIPALEAALSALDTLKPADITIVKSMKNPPSGVKLVMAAICVMKDIKPEKITDPAGTGGKILDYWGPSKKVLGDMNFLRDLKEYDKDNIPVSVMQKIRGEYLTNPEFDPPKVAKASSAAEGLCKWIMAMEVYDRVAKVVAPKKARLAEAQKSLGETMNLLNQKRAELKAVEDRLANLQQTFLEKTEEKVRLEDQVELCAKKLERASKLIGGLGGEKTRWSKAADDLQNTYDNLTGDVLISAGVIAYLGAFTAGFRHECTKDWSRLCKEKEIPCSDDFSLSKILGDPVKIRAWNIAGLPTDAFSIDNGVIVSNSRRWPLMIDPQGQANKWIKNSERENQLSVIKLSDSDYMRTLENCIQFGAPLLLENVGEELDPSLEPLLLRQTFKQGGIDCIRLGEVTIEYSFDFKFYITTKLRNPHYMPELATKVSLLNFMITPEGLEDQLLGIVVAKERPELEEERNALILQSAANKKQLRDIESKILETLSSSEGNILEDESAIKVLDSAKLMSNEILKKQQIAEKTEIKIAESREGYRPIAKHSSVLFFSIADLANIDPMYQYSLSWFVNLYINSIHDSNRSKILEKRLRYLNDHFTYNLYCNVCRSLFEKDKLLFSFLLCANLLLAKKEIEYSEFMFLLTGGIGLKSPEGNPDPTWLPEKSWEELCRASELPAFKDLREHFQKNIGDWHEIYDSKEPHMVPFPKPLDTNLNELQKIIVLRCLRPDKISPAITNYVTDKLGKKFVEPPPFDLAKSYLDSNCTIPLIFVLSPGADPMASLLKFANDKNMSANKFQAISLGQGQGPIAARMIRESIEEGTWVCLQNCHLAVSWMPMLEKICEDFSAETCQPAFRLWLTSYPSEKFPVTILQNGVKMTNEPPTGLRLNLLQSYLTDPISDLQFFKGCPGKEQVWEKLLFGVCFFHALVQERKKFGPLGWNIPYGFNESDLRISVRQLQLFINEYEDVPFEAISYLTGECNYGGRVTDDWDRRLLLTILADFYNPEIIKNPHYMFSPSGNYYAPPRGTYDDYIEFIKKLPFTQQPEIFGLHENVDISKDLHQTKTLFESLLLTQGGTTQSGSSASADATLLEITHDILGKPEQNDPPHFAQPGESDQGAGGYGFGA","proteome":"UP000515140","gene":"DNAH12","go_terms":[{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008569","name":"minus-end-directed microtubule motor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007018","name":"microtubule-based movement","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0030286","name":"dynein complex","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0045505","name":"dynein intermediate chain binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051959","name":"dynein light intermediate chain binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"3c08b58af4e7a833f0a00e3390cb0cb7c8f247cb","counters":{"domain_architectures":123,"entries":42,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":12,"pfam":10,"ssf":1,"smart":1,"cdd":1,"panther":1,"interpro":16},"proteome":1,"taxonomy":1,"similar_proteins":123}}}