{"metadata":{"accession":"A0A6P4IAX0","id":"A0A6P4IAX0_DROKI","source_organism":{"taxId":"30033","scientificName":"Drosophila kikkawai","fullName":"Drosophila kikkawai (Fruit fly)"},"name":"Succinyl-CoA:glutarate CoA-transferase","description":["Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors. Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate. Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis"],"length":446,"sequence":"MLSQRLRLGRGLVNYGASGRQSLRNFAAAAGDDNNNNNNNNKSSNDSVDERHPLQGIRILDLTRIIAGPYCTMVLADLGAEVIKVERPHYGDEARKWGPPFLEHSQDAAYFLAPNRNKRSVCIDLKRGTKMLHKLAEMSDVLVENYVPGTLDRYGLGYEQLRKVNPKLIYCSLTGYGSVGPYAKRPGYDVIASSVGGLLHITGERDGPPSKVGVAVTDISTGLYAHGAILAALYQRTRTQRGQKIDVDLLSTCCSLLINVGSNYLNAGTEAKRWGTAHSSIVPYQAFKAKDGYLTLGAGSDAQFKDLCRRLQVEHLSEDPKFKTNKDRVQNREEIVSILEKILSKDTAHNWMKVFEGAPFPVGPVNNIGQVFEDEHIQAIGLVKTLPHPKDDFVKVVGPPVVFSEARNDARTAPPMRGQHTDEVLGELLGYGREEIAKLREDDIIE","proteome":"UP001652661","gene":"LOC108072976","go_terms":[{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e15f2aec4310ca0156719fd0f208596489f1c4ae","counters":{"domain_architectures":85455,"entries":9,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":2,"panther":1,"pfam":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":85455}}}