{"metadata":{"accession":"A0A6P3WB43","id":"A0A6P3WB43_CLUHA","source_organism":{"taxId":"7950","scientificName":"Clupea harengus","fullName":"Clupea harengus (Atlantic herring)"},"name":"Transforming growth factor beta","description":["Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1","Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3. Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3","Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively","Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal"],"length":410,"sequence":"MHLGRAVLFFLLLNCVTMTLSLSTCTTVDIDHIKKKRVEAIRGQILSKLRLTSPPQALGPNHVPFQVLALYNSTRELIEELGLHRQQSCGQDNTETEYYAKEIYKFNMIQGLPENNDLPYCPKGITSRVFRFNVSAMEKNSTNLFRAEFRALRVPNSSAKKNEQRIEMYQILRQDEHIAKQRYIGGKNVLTKGAPEWVSFDVTETVREWLTNRDSNLGLEISVHCPCHTFNPNGDITENVNEVLDVKFKGAEGEYEENSRWDLGHLKKQKEQLLPHLILMMLPPHRLDAQASSRRRKRALDTNYCFNNYEENCCVRELYIDFRRDLGWRWIHEPKGYYANFCSGPCPYLRSADNTHSSLLSLFNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMIVKSCKCS","proteome":"UP000515152","gene":"tgfb3","go_terms":[{"identifier":"GO:0008083","name":"growth factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005615","name":"extracellular space","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005576","name":"extracellular region","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005160","name":"transforming growth factor beta receptor binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"04593996051ce3d4910e9a15791ebc858e9f199a","counters":{"domain_architectures":22751,"entries":20,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":1,"ssf":1,"cdd":1,"pfam":2,"smart":1,"pirsf":1,"panther":1,"prints":2,"prosite":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":22751}}}