{"metadata":{"accession":"A0A6P3PY29","id":"A0A6P3PY29_PTEVA","source_organism":{"taxId":"132908","scientificName":"Pteropus vampyrus","fullName":"Pteropus vampyrus (Large flying fox)"},"name":"S-(hydroxymethyl)glutathione dehydrogenase","description":["Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation"],"length":379,"sequence":"MRTENMAKQVIQCKAAIAWEAGKPLSIEEVEVAPPKAHEVRIKIIAFAICHTDAYTLSGADPEGNFPVILGHEGAGIVESVGDGVTNLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAVVNTAKVEPGSTCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFAKAKEFGASECINPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTYNLSFDQINKAFELLHSGMSIRSVVKF","proteome":"UP000515202","gene":"ADH5","go_terms":[{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051903","name":"S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0046294","name":"formaldehyde catabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6e6b076d581cf5733167d9dad5b9a31c66e6d8d3","counters":{"domain_architectures":323634,"entries":16,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cdd":1,"cathgene3d":2,"pfam":2,"panther":1,"ncbifam":1,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":323634}}}