{"metadata":{"accession":"A0A6P3PV37","id":"A0A6P3PV37_PTEVA","source_organism":{"taxId":"132908","scientificName":"Pteropus vampyrus","fullName":"Pteropus vampyrus (Large flying fox)"},"name":"G1/S-specific cyclin-D3","description":["Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4"],"length":292,"sequence":"MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTQKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSISGDELTELLAGITGTEVDCLRACQEQIEAALRESLREAAQTSPSPAPKAPRGSSSQGPSQTSTPTDVTAIHL","proteome":"UP000515202","gene":"CCND3","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"fd1efc4a1ce5c8e2dc0db0172d8c97e704be840e","counters":{"domain_architectures":39207,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"ssf":1,"cathgene3d":1,"pfam":2,"smart":2,"panther":1,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":39207}}}