{"metadata":{"accession":"A0A6P3IJW0","id":"A0A6P3IJW0_BISBB","source_organism":{"taxId":"43346","scientificName":"Bison bison bison","fullName":"Bison bison bison (North American plains bison)"},"name":"Atrial natriuretic peptide receptor 3","description":["Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production"],"length":536,"sequence":"MPSLLVLTFSACVLLGWALLAXXXXXXXXXXXGPGRGRREREALPPQKIEVLVLLPQDDSYLFSLARVRPAIEYALRSVESNATGRRLLPAGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPSYAKMGEMMLALFRHHQWSRAVLVYSDDKLERNCFFTLEGVHEVFQEEGLHTSAYNFDETKDLDLEDIVRHIQASERVVIMCASSDTIRAIMLAAHRHGMTSGDYAFFNIELFNSSFYGDGSWKRGDKHDFEAKQAYSSLQTITLLRTVKPEFEKFSMEVKSSVEKQGLSEEDYVNMFVEGFHDAILLYVLALREVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVIAMTDTEAGTQEVIGDYFGKEGRFEMRPNVKYPWGPLKLRIDETRMVEHTNSSPCKACGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNQQEESNVGKHRELREDSIRSHFSVA","proteome":"UP000515208","gene":"NPR3","go_terms":[{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"234a85239583fe6ce8edca72fdfb80dc6a32599e","counters":{"domain_architectures":17597,"entries":11,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"pfam":1,"panther":1,"prints":1,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":17597}}}