{"metadata":{"accession":"A0A6P3HA51","id":"A0A6P3HA51_BISBB","source_organism":{"taxId":"43346","scientificName":"Bison bison bison","fullName":"Bison bison bison (North American plains bison)"},"name":"Glycerophosphodiester phosphodiesterase 1","description":["Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol. Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity. Has little or no activity towards glycerophosphocholine"],"length":331,"sequence":"MWLWEEQGGLMGPFSFLLLVLLLLTRSPFNACLFTGSLYLLLRLFSFEPVPSRRAMQVLKPRDRVSAIAHRGGSHDAPENTLAAIRQAAKNGAAGVELDLEFTADGIPVLMHDSTVDRTTDGTGRLCDLTFEQIRKLNPAANHRLRNDFPNEKIPTLREAVAECLNHNLTIFFDVKGHAYKATDALKKVYMEFPKLYNNSIVCSFLPEVIYKMRQTDQNVVTALIHRPWSLSHTGDGKPRFESFWKQSMFVALDILLDWSMHNILWYLCGVSAFLAQKDFISPDYVKKWSAKGIQVVAWTVNTFDEKSYYESHLGSSYITDSMLEDCTPEF","proteome":"UP000515208","gene":"GDE1","go_terms":[{"identifier":"GO:0008081","name":"phosphoric diester hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006629","name":"lipid metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4211b9756adb83454d57d518ce749501fd9ed8a7","counters":{"domain_architectures":68019,"entries":8,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"profile":1,"ssf":1,"cdd":1,"panther":1,"pfam":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":68019}}}