{"metadata":{"accession":"A0A6P3FGI5","id":"A0A6P3FGI5_OCTDE","source_organism":{"taxId":"10160","scientificName":"Octodon degus","fullName":"Octodon degus (Degu)"},"name":"Serine--tRNA ligase, cytoplasmic","description":["Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA"],"length":525,"sequence":"MALSVRPEAGKMVLDLDLFRVDKGGNPDLIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPEDVLDFDALTADALANLKVSQIKKVRLLIDEAILKCDAERLKLEAERFENLREIGNLLHPSVPISNDEDADNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAIVAGSRGYFLKGVLVFLEQALIQFALRTLASRNYVPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYASPHDNKSWEMFEEMIATAEEFYQALGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGILVPEKLKEFMPPGLQELIPFVKPAPIDQEPSKKQKKQHEGSKKKAAARDVTLESQLQSMEVTEA","proteome":"UP000515203","gene":"Sars","go_terms":[{"identifier":"GO:0000166","name":"nucleotide binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004812","name":"aminoacyl-tRNA ligase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006418","name":"tRNA aminoacylation for protein translation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004828","name":"serine-tRNA ligase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006434","name":"seryl-tRNA aminoacylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"abd0a67fe18a7ecd4ebd3536c1b1a039805449ac","counters":{"domain_architectures":33871,"entries":20,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"pfam":2,"ssf":2,"cdd":1,"profile":1,"pirsf":1,"panther":1,"ncbifam":1,"prints":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":33871}}}