{"metadata":{"accession":"A0A6P3ETX8","id":"A0A6P3ETX8_OCTDE","source_organism":{"taxId":"10160","scientificName":"Octodon degus","fullName":"Octodon degus (Degu)"},"name":"Protein disulfide-isomerase","description":["Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity"],"length":505,"sequence":"MRSHRLRLLPGVALLLATARLAAASDVIELTDDNFESRVSDTGTAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVTGYPTLKIFRDGEESGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFINDKDGAVVGFFRDLFSEAHSEFLKAASNLRDNYRFAHTNVESLVKEYDDNGEGITLFRPLHLANKFEDKTVAYTEQKMTSGKIKKFIQENIFGMCPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVVAESFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKQSPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQEDL","proteome":"UP000515203","gene":"Pdia3","go_terms":[{"identifier":"GO:0003756","name":"protein disulfide isomerase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"0f03827d65a019e26af5a921c57f26641291fa17","counters":{"domain_architectures":9480,"entries":19,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cathgene3d":1,"ssf":1,"pfam":2,"cdd":3,"panther":1,"ncbifam":2,"prints":1,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":9480}}}