{"metadata":{"accession":"A0A6J3S3C9","id":"A0A6J3S3C9_TURTR","source_organism":{"taxId":"9739","scientificName":"Tursiops truncatus","fullName":"Tursiops truncatus (Atlantic bottle-nosed dolphin)"},"name":"Selenocysteine-specific elongation factor","description":["Translation factor required for the incorporation of the rare amino acid selenocysteine encoded by UGA codons. Replaces the eRF1-eRF3-GTP ternary complex for the insertion of selenocysteine directed by the UGA codon. Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling. (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation. (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur"],"length":585,"sequence":"MAGRRVNVNVGVLGHIDSGKTALARALSTTASTAAFDKQPQSRERGITLDLGFSCFSVPLPARLRPAPLGAEPEPGAEPRLQVTLVDCPGHASLIRTIIGGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKTDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAPIIPVAARPGGPDAPETEAPQGIPELIELLTSQISIPRRDPSGPFLMSVDHCFSIKGQGTVMTGTILSGSVSLGDSVEIPTLKVVRKVKSMQMFHTPVTSAVQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALVSVEKIPYFRGSLQTKAKFHITVGHETVMGRVMFFSPAPDGFDHEPVLDSFDFSQEYLFQEQYLCPGSVPAETDGGEADRRVGQASEGRCPRQQWALVEFEKPVTCPRLCLVIGSRLDADIHANTCRLAFHGVLLHGLEDKNYAESALPRLRVYKLKHKHGIVERVMDDYSVIGRSLFKKETNIQLFVGLKVQLSTGELGVIASAFGQSGKFKVHIPGGLSPESKKILTPTLKKRGRAGRGEEAGQPEPVQHVALSLSFKRYVFDTHKRMVQSP","proteome":"UP000245320","gene":"EEFSEC","go_terms":[{"identifier":"GO:0003924","name":"GTPase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005525","name":"GTP binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"19254744b5c31bee03c0fad44548a0c3f9abc80b","counters":{"domain_architectures":1142,"entries":21,"isoforms":0,"proteomes":1,"sets":6,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cathgene3d":2,"ssf":2,"cdd":3,"pfam":4,"panther":1,"prints":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":1142}}}