{"metadata":{"accession":"A0A6J3RN65","id":"A0A6J3RN65_TURTR","source_organism":{"taxId":"9739","scientificName":"Tursiops truncatus","fullName":"Tursiops truncatus (Atlantic bottle-nosed dolphin)"},"name":"CASP8 and FADD-like apoptosis regulator","description":["Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity"],"length":297,"sequence":"MQSVASWPSVDWTRFFLPLFLGMTLYRMSAEVIHQVEEALDEDEKELLLFLCRDVAADVVPLNVRDLLDVLRERGKLSFVSLAELLYRVRRFDLLKRVLKMDRPTAEALLRRHPHLISDYRVLLMEIGEGLDKSDVSSLIFLMRDYMGRGKIAKDKSFLDLVIELEKLNLVAPDHLDLLEKCLRNIHRIDLKTKIQKYKQSAQGVETNYVNALQASLPNLSVKDPSYNLRFQNGRSKEHRLMTGQRDIQREPVKTSIQESEAFLPQHILEERYKMQSEPLGICLIIDCIGNDTGGCA","proteome":"UP000245320","gene":"CFLAR","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0042981","name":"regulation of apoptotic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e76d7634d868c667c1ade5bbba209d0b5f9af0cb","counters":{"domain_architectures":377,"entries":10,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"smart":1,"profile":1,"cdd":2,"pfam":1,"ssf":1,"panther":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":377}}}