{"metadata":{"accession":"A0A6J3R7M3","id":"A0A6J3R7M3_TURTR","source_organism":{"taxId":"9739","scientificName":"Tursiops truncatus","fullName":"Tursiops truncatus (Atlantic bottle-nosed dolphin)"},"name":"DNA-binding protein RFX2","description":["Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export","Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene H1-6"],"length":1242,"sequence":"MQNSEGGSDSPASVALCPSSAAQAPVAQPVPASPQRVLVQAAGSAPKGAQMQPISLPRVQQVPQQVQPVQHVYPPQVQYVEGGEAVYTNGALRTAYAYNPEPQMYAPSSSASYFEAPGGAQVTVAGSSPTAVPAHSMVGITMDVGGSPIVSGTGAYLIHGGMDGTRHALAHTSRSSPATLEMAIENLQKSEGITSHKSGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPVHQKPRYRPAQKTDSLGESGSHGSLHSTPEQAMAAQSQHHQQYIDVSHVFPEFPAPDLGSVLLQENITLHDIKALQLAYRRHCEATLDVVMNLQFHYVEKLWLSFWNSKASSGDGPASLPTSDEEPEGAVLPKDKLVSLCKCDPVLRWMRTCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVGAFAQTLRRYTSLNHLAQAARAVLQNTAQISQMLSDLNRVDFANVQEQASWVCQCEEGVVQRLEQDFKLTLQQQSSLDQWASWLDNVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDLASLSLTLLDKVFQEKPAIAPPVFVFQKDKGQKSSAEQKDLSDSGEESRGEAEAPHHGTGHPESAGEHALELPAPASASASAPEAQLPPFPRELAGRSAGGSSPEGGEDSDREDGNYCPPVKRERTSSLTQFPPSQSEEKSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAPQPKVLSQTVPSSGTNGVSVPADCPGAATSASPDNPARRSPSDEAPALEEKDLQKNESSSASEESCEKKELAQQAFVFGQNLRDRVKLINENAEVVDMENAGHPSSEAPAATNYFLQYISSSLESSANSADAASSKFIFGQNMSERVLSPPKLNEVSPDANRENTVAESGSESSSQEATPEKESLAESAAAYTKATARKCLLEKVEVITGEEAESNVLQIQCKLFVFDKTSQSWVERGRGLLRLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQMDKASEKSIRITAMDTEDQGVKVFLISASSKDTGQLYAALHHRILALRSHVEQEQEARTPAPEPGAAPSNEDDSDDDDVLAPSGATGGGAGDEGDGQTAGST","proteome":"UP000245320","gene":"LOC101333468","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0046907","name":"intracellular transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0003700","name":"DNA-binding transcription factor activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"b9e32f2bcf3fb7d3636d112ec34e534bad542af9","counters":{"domain_architectures":6,"entries":21,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"pfam":4,"cathgene3d":2,"profile":2,"ssf":2,"smart":1,"cdd":1,"panther":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":6}}}