{"metadata":{"accession":"A0A6J3PYK2","id":"A0A6J3PYK2_TURTR","source_organism":{"taxId":"9739","scientificName":"Tursiops truncatus","fullName":"Tursiops truncatus (Atlantic bottle-nosed dolphin)"},"name":"Kremen protein","description":["Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation"],"length":461,"sequence":"MGTRAPQGLLLLLLLRLLLPRGTSAGSLHNPGLSECFQVNGADYRGHQNRTGPRGAGRPCLYWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPTCHMPGYLGCFVDSGAPPALSGPSGTSTKLTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDLARGRPASATDCDQICFGHPGQLCGGDGRLGIYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGPPGAALELTFRLFELADQRDQLELRDAASGSLLRAFDGTRPPPPGPLRLRSVALLLTFRSDARGHAQGFALTYRGLQDADDPAPPKGSAQTPAGPPDGANVSCSPRPGTPEAAIGAQVFLTVTAVSVLLLLLLSLLRLLRGRSCLLAPGKGPPALGPSRDPARSWAVWYRRPRGVALPCPPGDPQVESLTASYRPLSASSQSSLRSLISAL","proteome":"UP000245320","gene":"KREMEN2","go_terms":[{"identifier":"GO:0016055","name":"Wnt signaling pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"39496a1f3456e516901af49df2e788367bc65be7","counters":{"domain_architectures":1001,"entries":28,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cathgene3d":2,"smart":3,"cdd":2,"profile":3,"pfam":3,"pirsf":1,"panther":1,"prints":1,"prosite":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":1001}}}