{"metadata":{"accession":"A0A6J3PRM6","id":"A0A6J3PRM6_TURTR","source_organism":{"taxId":"9739","scientificName":"Tursiops truncatus","fullName":"Tursiops truncatus (Atlantic bottle-nosed dolphin)"},"name":"Pseudouridylate synthase 1 homolog","description":["Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA"],"length":431,"sequence":"MGLPSLRAAAWALRRACGPWTPRLGPRLLCLPPMAGNGEAPVPVGTKQEQDRKVRRGWQGAARIWEETEQQAKRLRSSEGGGQHRKLPKRKVVLLVAYSGKGYHGMQRNVGSSKFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDLLEKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYFYMLPTFAFAHKDHDAQDETYRLHAETLGHVNRLLACYRGTHNFHNFTSQKGPREPSARRYILDMFCEEPFVREGMEFAVIKVKGQSFMTHQIRKMVGLVVAIVKGYAPESVLERCWGEAKVDVPKAPGLGLVLERVHFEKYNQRFGHDGLHEPLDWAREEAEVTAFKEQHIYPTIIGTERHERSMAQWLSTLPMHDFSATAHAAAGPGAKVPRPLEGSDGDSD","proteome":"UP000245320","gene":"PUS1","go_terms":[{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009982","name":"pseudouridine synthase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0001522","name":"pseudouridine synthesis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0009451","name":"RNA modification","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0031119","name":"tRNA pseudouridine synthesis","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"19256404772d8c42f87a117f633a8ad0cab47de9","counters":{"domain_architectures":18208,"entries":13,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":1,"cdd":1,"pfam":1,"panther":1,"ncbifam":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":18208}}}