{"metadata":{"accession":"A0A6J3JGP4","id":"A0A6J3JGP4_SAPAP","source_organism":{"taxId":"9515","scientificName":"Sapajus apella","fullName":"Sapajus apella (Brown-capped capuchin)"},"name":"Interleukin-1 receptor accessory protein","description":["Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling","Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells"],"length":572,"sequence":"MWMTLLWYVMSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARVKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVQKLYIEYGIQKITCPNVDGYFPSSVKPTITWYMGCNKIQNFHNVVPEDMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKIVGSPKNAGPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLIDSRNEVWWTIDGKKPDDITVDVTINESISHSRTEDETRTQILSIKKVTSEDLKRNYVCHARSTKGEVAKAAKVKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKRSPRRSSSDEQGLSYSSLKNV","proteome":"UP000504640","gene":"IL1RAP","go_terms":[{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004908","name":"interleukin-1 receptor activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"aea1e35d4caf3450ef8d7d1bf67a3316673def8d","counters":{"domain_architectures":819,"entries":25,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"cdd":3,"smart":2,"ssf":2,"pfam":2,"profile":2,"panther":1,"prints":2,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":819}}}