{"metadata":{"accession":"A0A6J3JC68","id":"A0A6J3JC68_SAPAP","source_organism":{"taxId":"9515","scientificName":"Sapajus apella","fullName":"Sapajus apella (Brown-capped capuchin)"},"name":"Proenkephalin-A","description":["Increases glutamate release in the striatum and decreases GABA concentration in the striatum","Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release","Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress"],"length":267,"sequence":"MARFLRLCTWLLLLGPGLLATVRAECSQDCATCSYRLVRPADINFLACVMECEGKLPSLKIWETCKELLQLSKPELPQDGTSTLRESSKPEEGHLLAKRYGGFMKRYGGFMKKMNELYPMEPEEEANGSEILAKRYGGFMKKDAEEDDSLAKSSDLLKELLETGDNRERSHHQDGSDNEEDVSKRYGGFMRGVKRSPQLEEEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEALPSDEEDGSYSKEVPEMEKRYGGFMRF","proteome":"UP000504640","gene":"PENK","go_terms":[{"identifier":"GO:0007218","name":"neuropeptide signaling pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6fa08cbd40ae6cd5bb2038f6d2313e3785d0712e","counters":{"domain_architectures":2355,"entries":7,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"panther":1,"pfam":1,"prosite":1,"prints":2,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":2355}}}