{"metadata":{"accession":"A0A6J3EQS7","id":"A0A6J3EQS7_AYTFU","source_organism":{"taxId":"219594","scientificName":"Aythya fuligula","fullName":"Aythya fuligula (Tufted duck)"},"name":"Sodium/potassium-transporting ATPase subunit beta","description":["The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle","This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane"],"length":288,"sequence":"MATLNEKKTCSERMENFRRFVWNPETKLFMGRTLINWVWISLYYLAFYVVMTGLFALSIYSLMRTVNPYEPDYQDQLKSPGVTLRPDVYGDRGLQIYYNTSENKTWERLVTTLQTFLTAYTPAAQHLNINCTGDKYFIQDTFDGPNNTKLSCKFTSDMLQNCSGITDPTFGFPEGKPCFIIKMNRIIKFYPGNGTAPRVDCTYVGDESRPLEVDYYPANGTFNLHYFPYYGKKAQPTYSNPLVAVKFLNLTRNVELKIVCKIIGAGITFDNVHDPYEGKVEFKLKIED","proteome":"UP000504639","gene":"ATP4B","go_terms":[{"identifier":"GO:0006813","name":"potassium ion transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006814","name":"sodium ion transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005890","name":"sodium:potassium-exchanging ATPase complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"edc17df419148265b8eea0f3941c45befc5b4f1c","counters":{"domain_architectures":7100,"entries":9,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ncbifam":1,"panther":1,"pfam":1,"prosite":2,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":7100}}}