{"metadata":{"accession":"A0A6J3CPB8","id":"A0A6J3CPB8_AYTFU","source_organism":{"taxId":"219594","scientificName":"Aythya fuligula","fullName":"Aythya fuligula (Tufted duck)"},"name":"Galectin","description":["Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans"],"length":296,"sequence":"MMSLDGPQKTIINPVIPYVGTILGGLVPGELIVIHGSVPDDADRFQVDLQCGSSIKPRADVAFHFNPRFKRSGCIVCNTLEREKWGWEEITYEMPFEKGKSFEVAIMILKDKFQVTVNKKHLLLYNHRISLQRIDTLGIYGKVHIKSIEFVSNGEMPDGSQFGVPYIGKLDSALRPGCTIAIKGEMNKNPKSFAINLKSSESKDIALHLNPRMKNKVFVRNSYLRDSWGEEEREVTNFPFSPGMYFELIIFCDAHQFKVAVNGVHILEYKHRFKQLEKIDLLEVTGDVQLLDVRSW","proteome":"UP000504639","gene":"LGALS8","go_terms":[{"identifier":"GO:0030246","name":"carbohydrate binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ffbb8fdb6dace06ffe9c196dae065f4979c74328","counters":{"domain_architectures":5613,"entries":11,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"smart":2,"cdd":1,"pfam":1,"profile":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":5613}}}