{"metadata":{"accession":"A0A6J2VF67","id":"A0A6J2VF67_CHACN","source_organism":{"taxId":"29144","scientificName":"Chanos chanos","fullName":"Chanos chanos (Milkfish)"},"name":"Proteasome activator complex subunit 4B isoform X2","description":["Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved in DNA damage response in somatic cells: binds to acetylated histones and promotes degradation of histones"],"length":1827,"sequence":"MKKDPVETIGFIPQKDIIYNKLLPYADRLDNESNELLAKIKGNLGRAVQLRELWPGVLFWTRKLSTYLRLYGRKFSKEDHVLFIKLLYELVTIPKLEISMMQGFARLLINLLKKKELLSRDDLELPWRPLYELYERILYSKTEHLGLNWFPNSVENVLKTLVKSCRPYFSESATQEMLDEWRPLLCPFDVTMQKAVGYFELFLPTIMPPEQHDKGFKLWFDELMDLWVSVQNLPSWEGNLVNLFARLANDNIGYVNWDPYIPKIFTRILRSFNLPVGSSQMIVPRYLTNSYDIGHVVLWISSMLGGPGNQAQKQLNGLFSSIASFYHPSNNGRWLMKLMKLLQRLPASVVRRLHRERYKKPCWITPVPASHRLTDQDVTDFVESMKQPVLMAMFSKTGSMDAAQALQNLALMRPELVIPPVLEKTYPAMETLTEPHQLTATLSCMIGMARSLLSGGRHYPEGPAHVLPLLMRALPGVDPNDFSKCMITFQFIATFTTLVPLVDCSSALHEKNDLTEMERELCSASAEFEDFVLQFMDRCFALIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSMEIFKVALEKVFNFATTNIFETRVAGRMVADMCRAASKCHPAESLRLFVPHCCSAITHITANEDVLNEEELDKELLWNLQLLSEVTRVDGEKLLPYRAQLVQILQLTLRLRCKQGYSLACNLLHHILRSTALIYPTDYCSVPGGFSRPLSEYLPIKDWGRPGDLWDLQIRWHVPSAEETEFVFYVLDLLLQPELQRLQRYAQGEQDMSRDDVLQSLSIVQHCLLGAGSMLPPLDGPPVTGLVPSLVSLEETKLFIGVNYDESRENYREAICKVMRQLLHHILEHSEDDTKSLFAIIKIISDLMHFKGSHKHEFDSRWKSFTLVKKSMENRLHGKKQHIRALLIDRVLLQHEMRKLLVEGCEYKTIHQDLLKDLLRLSTSTYSQVRSKAQSVFFTALGAYNFCCRDITPQVLQLLDPNRTDVTQQQFKGALYCLLGNHSGVCLGNLHDWDCIALTWPAMVRSGLSVAMSLEKPSIVRLFDDLADKVHRQYETIGIDFAVPDSTVLLAGRITESKAPVPNPGTPTDQEIEQGIALQQAKNLDSVQKYERLVSDLLECLDDRDLPWKFEHMAIGFLSLLLRDDHPLPAPAVLFFVQSLNHDALIVRKMAISSVGGILKQLKRPRKKVAVCPSEISGVTEPEGLIAGDRPGNEWLQYDTNKLPRSQQDWENFHFVEKTHWGYYTWPKKLMLYAPTAEQPNDLTPEDMNERERIIYDHFSDPGFIAQLIEFLALEDRKGKDKFNPRRFCLFKGLFRNYTDAFLPVLRPHMERLANDSHESTQRCVAEIIAGLVRGSKHWGYSKVEALWDFLIPLMRTALSKITVETYTDWGTCVATACESRDPRKLHRLLEMLMECPLSGEGGSFVDACHLYVLQGGLAQQEWRVPELLHRLLCYLEPKLTQVYKNVRERIGSVLTYIFMIDVMLPHTLPTKSPHISEFTQRVMCRLKPLLEGEEEIQNHVVEENGVGEQDERTQAIKLLKTVLKWLMASAGRSFSTPVSQQLQLLPLLFKIAPVENDDSYDELKRDAKTCLSLMSQGLLYPEQIPLVLQVLKEIAGSSSWHARFSVLTYLQIMVFYNLFTMLSSEQAVRDVRALVIRLLEDEQLEVREMAATTLSGFLQCNFLAMDASMQTHFEALCKTRLPKKRKRDRGSIVDTIPSVDLVRRHAGVLGLSACILSSPYDVPTWMPQLLMDLSAHLNDTQPIEMTVKKTLSNFRRTHHDNWLEHKQQFTDDQLLVLTDLLVSPCYYA","proteome":"UP000504632","gene":"psme4b","go_terms":[{"identifier":"GO:0016504","name":"peptidase activator activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0070628","name":"proteasome binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"7dfbb416ec31b39ccd5b9431745d09aa6d981790","counters":{"domain_architectures":2499,"entries":12,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"pfam":3,"cathgene3d":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":2499}}}