{"metadata":{"accession":"A0A6J2PZ72","id":"A0A6J2PZ72_COTGO","source_organism":{"taxId":"56716","scientificName":"Cottoperca gobio","fullName":"Cottoperca gobio (Frogmouth)"},"name":"OTU domain-containing protein 3","description":["Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination"],"length":358,"sequence":"MSRKQTPKPVRSNKKSELERKRDERAARRAIVKDRKNRPQDGDEGAEFVSFSNQLQALGLRLREVPGDGNCLFRALGDQLEGQSRGHLRLRQETVQYMMSHRQDFEPFVEDDVPFAQHLSNLSQPGTFAGNDAIVAFARSQQVKVVIHQLNAPLWEINGAEKQVCRELHIAYRYGDHYDSVRRTGDNSESPAQLRIENLQNSQGHQREFGDGQRDRRKNPSPTTSEEDNVILSSIKNRGIQGDEENLLQLSAATINAEWLVGSVLGQSCQGQCASGSCSACRAAATDYSEHKQSTEGSNIQKPKVSNKQRKDQQRLEKKKRQEDRHRQKFLQSKGSQDQNQNLPEAVTLVPALNTLSI","proteome":"UP000504630","gene":"otud3","go_terms":null,"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"0385c19cd1efb2670ef9513f5d43d80283d20182","counters":{"domain_architectures":22191,"entries":9,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"cdd":1,"profile":1,"pfam":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":22191}}}