{"metadata":{"accession":"A0A6J2PXQ9","id":"A0A6J2PXQ9_COTGO","source_organism":{"taxId":"56716","scientificName":"Cottoperca gobio","fullName":"Cottoperca gobio (Frogmouth)"},"name":"Beta-hexosaminidase","description":["Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A"],"length":540,"sequence":"MEGIMYMVRCGRYSRPHFNLLLLIILQLGLHTVDGVWPLPQKFTSSTERYSLNSQAFYFGYGKQSAAKQGCSVLDAAFKRYFPLIFPDYTSGNGVLRFNQEQAFTVEISVDHDDCESYPNEDTSEKYNLSVSAGQASLNAETVWGAVRGLETFSQLVYQDDFGSYFVNKTEIEDFPRFQFRGILLDTSRHYLPVQAILKTLDAMAYSKFNVFHWHIVDDPSFPYQSRTFADLSSKGAFHPMTHIYTQLDVKRVISHARLWGIRVLPEFDSPGHTQSWGKGQPGLLTPCYKGSTPSGSFGPVNPVLPSTYEFMAKLFKEVSLVFPDSYMHLGGDEVNFSCWRSNPDVRAFMQKMGFGQDFTKLEAFYMENIMNITSALNKTSIVWQDVFDYHERIPKDTVLHIWKGLPASYRDELSRMTKAGMRVLLAAPWYINHISYGQDWRNSYTVQPQNFSGTEEQKKLVIGGEVCMWGEYVDATNLSPRLWPRASAAAERLWSDEKQTFSVNKAFPRLQDFRCKLVRRGIKAEPLHIGHCKHEYEGV","proteome":"UP000504630","gene":"hexa","go_terms":[{"identifier":"GO:0004553","name":"hydrolase activity, hydrolyzing O-glycosyl compounds","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005975","name":"carbohydrate metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004563","name":"beta-N-acetylhexosaminidase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e0ead1903fc7cb9df47e360930fe2e9ce182c978","counters":{"domain_architectures":8880,"entries":15,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"pfam":2,"ssf":2,"cdd":1,"panther":1,"pirsf":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":8880}}}