{"metadata":{"accession":"A0A6J2LHX2","id":"A0A6J2LHX2_9CHIR","source_organism":{"taxId":"89673","scientificName":"Phyllostomus discolor","fullName":"Phyllostomus discolor (pale spear-nosed bat)"},"name":"Integral membrane protein 2","description":["Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation"],"length":271,"sequence":"MVKISFQPAVAGVKGDKADKASASASAAAPATGPAAEILLTPAREERPPYHRHKKGGSVGSVCYLSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFHCGVFYEDSLSSQAHTRMELEEDVKIYLEDNYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVSDKEALGSFIHHLCNGKDTYRLRRRATRRRISKRGAKRCNAIRHFENTFVVETLICGAA","proteome":"UP000504628","gene":"ITM2C","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"883524b6fbdaf50d6c9f78577c11053e90ab5e79","counters":{"domain_architectures":7990,"entries":7,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"smart":1,"profile":1,"pfam":1,"panther":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":7990}}}