{"metadata":{"accession":"A0A6J2CNJ5","id":"A0A6J2CNJ5_ZALCA","source_organism":{"taxId":"9704","scientificName":"Zalophus californianus","fullName":"Zalophus californianus (California sealion)"},"name":"YjeF N-terminal domain-containing protein 3","description":["May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence. May play a role in spermiogenesis and oogenesis"],"length":297,"sequence":"MAAHSAFAAPPDWRKHRVGGEEAPVPWDALKRLWLWQLGFGHRLTSAMSSAARLDPTEAPEERRFLSTAEAAALERELLEDYRFGRQQLVELCGHASAVAVTKVFPLPTLSRKQRTVLVVCGPEQNGAVGLVCARHLQMFEYEPTIFYPTRSLDLLHRDLTTQCEKMDIPFLSYLPTEVQLINDAYGLVVDAVLGPGVQPGEIGGPCTRTLAILKLLSIPLVSLDIPSGWDAETGGGDTEDGLRPDVLVSLAAPKRCAGRFSGRHHFVAGRFVPDDVRRKFALRLPGYTGTDCVAAL","proteome":"UP000515165","gene":"YJEFN3","go_terms":null,"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e7453cc5cd7c5d6972de4186d4b6d2d166d9201e","counters":{"domain_architectures":6641,"entries":9,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"profile":1,"pfam":1,"panther":1,"ncbifam":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":6641}}}