{"metadata":{"accession":"A0A6J1YIE8","id":"A0A6J1YIE8_ACIJB","source_organism":{"taxId":"32536","scientificName":"Acinonyx jubatus","fullName":"Acinonyx jubatus (Cheetah)"},"name":"Histone-lysine N-methyltransferase ASH1L","description":["Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The physiological significance of the H3K9me1 activity is unclear"],"length":2996,"sequence":"MDPRNTAMLGLGSDSEGFSRKSPSAVGTGTAVSKREGELENNAKEEEDLRKWNRERNSEAGKEDGLTDAQQQFSVKETNFSEGNVKLKIGLQAKRTKKPPKNLENYVCRPAIRTTIKHPRKALKSGRMTDAKNEPCPPKRDPSKLYKKAGDVAAIECQSEEGIRLHSQGENSPLSKKLSPVHSEMTDYINATSSTLVGSREPDLKDRALLNGGTSVTEKLAQLIATCPPSKSSKTKPKKLGTGTAAGLVSKDLIRKAGVGSVAGILHKDLIKKPAISTAVGLVTKDPGKKPVFNATVGLVNKDSVKKLGTGTTAVFINKDLGRKPGTVTTVGLLSKDSGKKLGIGIVPGLVNKDSGKKLGLGTVVGLVNKDLGKKLSSTVGLVAKDCAKKIVANSAMGLVNKDMGKRLVSCSVAGLVSKDAINLKAEALLPTQEPLKASCSTNISSHESQELSESLKDSTTSKTFEKNVVRQSKESILEKFSARKEIMNLEKEMFSEGARIQQDSFSSSDRGPYEPSKHEQQPPVYCTSPDFQMGAASDASTAKSPFSAVGESSLPSPSPTVSVNPLTRSPPETSQLAPNPLLLSPSTELMEEISESVGKNQFTPESTHLNIGHRSVGHSMNIECKGIDKELTDSKTAHLDIPRISSSLGKKPSLTSDSSIHAITPSVVNFTSLFSNKPFLKLGAVGASDKHCQVAESLGTSLQSKPLKKRKGRKPRWTKVVARSTCRSPKGLELERSELFKNVACSSLSGSNSEPAKFMKTIGPSSFVDHDFLKRRLPKLSKATAPSLALLTDSEKPAHKAFATHKLSSSMCVSSDLLSDIYKPKRGRPKAKEMPQLEGPPKRTLKIPASKVFSLQSKEEQEPPILQPEIEIPSFKQSLSVSPFPKKRGRPKRQMRSPVKMKPPVLSVAPFVATESPSKLESESDNHRSSSDFFESEDQLQDPDDLDDRHRPAVCSMSDLERDPDKKMTKRNNGQLMKTIIRKINKMKTLKRKKLLNQILSSSVESSSKGKVQSKLHNTVSSLAATFGSKLGQQINVSKKGTIYIGKRRGRKPKTVLNGILSGSPTSLAVLEQTAQQAAGSALGQILPPLLPSSASGSEILPSPVCSQSSGTSGGQSPVSSDAGFVEPSSVPYLHLHSRQGSMIQTLAMKKASKGRRRLSPPTLLPNSPSHLSELTSLKEATPSPISESHSDETIPSDSGIGTDNNSTSDRAEKFCGQKKRRHSFEHVSLIPPETSTVLSSLKEKHKHKCKRRNHDYLSYDKTKRQKRKRKKKYPQLRSRQDPDFIADLEELISRLSEIRITHRSHHFIPRDLLPTIFRINFNSFYTHPSFPLDPLHYIRKPDLKKKRGRPPKMREAMAEMPFMHSLSFPLSGTGFYPSYGMPYSPSPLTATPLGLGYYGRYPPTLYPPPSPSFTPPLPPPSYMHAGHLLLNPTKYHKKKHKLLRQEAFLTTSRTPLLSMSTYPSVPPEMAYGWMVEHKHRHRHKHREHRSSEQPQVSMDAGSSRSVLESLKRYRFGKETVGERYKHKEKHRCHMSCPHLSPSKSLINREEQWVHREPSESSPLALGLQTPLQIDCSESSPSLSLGGFTPSSDPASSDEHTNLFTSAIGSCRVPNPNSSGRKRLADSPGLFSAQDTSLTRPHRKEPLPSGERAVQTATGSQPTSEKSSQRLSESTSSSPARKRSSSESTSSTVNGVSSRSPRATASGDDSVDGLLQRMVQHEDQAPLAKSVEAAITSASVPPSSSPGHGHGHGKERAPGRPDSLLAPAVPGDSCSGSISPLSERLPSSRSPPHIKRSVVEAMQRQARKMCNYDKILATKKNLDHVNKILKAKKLQRQARTGNNFVKRRPGRPRKCPLQAVVSMQAFQAAQLVGPELSEGEERAAAPFRPDTVTDVIEAVVQSVNLSPEQKKGLKRKSWLLEEQTKKKQKPFPEEERERTESFTETTVEIPGPPETPAKPPEPEGSLQPVLSLIPREKKAPRPPKKKYQKAGLYSDVYKTADPKSRLIQLKKEKLEYSPGEHEYGLFPAPIHVVVNNAAVNIGLQFSVEDPAFNSFVYIPRSGLAGSFGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRMNGLTSSKSSQPVATHKKSGRSKEKRKSKHKLKKRRGHLSEEPSENINAPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKPASEDVHSASLCTRWNSVCRDDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENIEVARAARLAQIFKEICDGIISYKDPSRQVLAAPLLSLPPKKKNADYYEKISDPLDLATVERRILTGHYKTVEAFDADMLKVFRNAEKYYGRKSPIGRDVCRLRKTYYNARHEASAQIDEIVGETASEADGSEASVSEKENVHEKDDDVIRCVCGLHKDEGLMIQCDKCMVWQHCDCMGVNSDVEHYLCEQCDPRPVDREVPMTPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKRDFSPHYVPDNYKRNGGRSSWKSERPKPPLKDLGQEDDALPLIEEVLASQEQAAEEMPGLEEPEREGAAAEAGEKKAEESSPEPAPACTPEERRHSQRERLNQILLNLLDKIPGKNAIDVTYLLEEGSGRKLRRRTLFIPESSFRK","proteome":"UP001652583","gene":"ASH1L","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0042054","name":"histone methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003682","name":"chromatin binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"ida_accession":"31a07a9e2a96abe7c08533eb2f51535f1d8abdf1","counters":{"domain_architectures":480,"entries":46,"isoforms":0,"proteomes":1,"sets":8,"structures":0,"taxa":1,"dbEntries":{"smart":6,"ssf":3,"cathgene3d":4,"profile":5,"pfam":6,"cdd":4,"panther":1,"prosite":1,"interpro":16},"proteome":1,"taxonomy":1,"similar_proteins":480}}}