{"metadata":{"accession":"A0A6J0UQD1","id":"A0A6J0UQD1_9SAUR","source_organism":{"taxId":"103695","scientificName":"Pogona vitticeps","fullName":"Pogona vitticeps (central bearded dragon)"},"name":"nucleoside diphosphate phosphatase","description":["Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP. In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER"],"length":427,"sequence":"MALSWITVIGIFALSSIYCILSHPDPETWFQDLFPLKVCPANTSVKTFYGIMFDAGSTGTRIHIYTFIQRSPENPAELEGEIFESVKPGLSAYADRPEKGAETVRQLLNMAKEVVPSSHWETTPVVLKATAGLRLLAEHKAEALLSEVRAVFEESPFLVPDNCVSIMDGTSEGILAWITVNFLTGQLYGQNPQTVGTLDLGGASTQITFLPQLEETLEQTPADFFTSFQMFNSTFKLYTHSYLGFGLKAARLATLGALEMEADGRMFRSSCLPKQLEAEWHFGGVRYRYGGKKEGKTGFEPCYSEVLRVVQGKLHQADEIQRSSFYAFSYYYDRAVDTDLIDYEKGGVLQVRDFERKAKEVCDNLDNYRSASPFLCMDLSYITALLKEGFGFGDNTVLQLAKKVNKIETGWALGATFHLLQSLGLSQ","proteome":"UP001652642","gene":"ENTPD5","go_terms":[{"identifier":"GO:0016787","name":"hydrolase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a977d00bde8672c76ffaaa6fe0b46fcc438a712c","counters":{"domain_architectures":20392,"entries":7,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"cathgene3d":2,"panther":1,"pfam":1,"prosite":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":20392}}}