{"metadata":{"accession":"A0A6J0I6L1","id":"A0A6J0I6L1_9PASS","source_organism":{"taxId":"321398","scientificName":"Lepidothrix coronata","fullName":"Lepidothrix coronata (blue-crowned manakin)"},"name":"Prosaposin","description":["Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate","Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases","Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12)"],"length":522,"sequence":"MARLLLLNLLGLLAAAVASPVLWQKECVKGPEVWCQSIRKASQCGAVKHCQQNVWNKPAVSSIPCDLCKELVTVAGKVLKDNGTEEEIRSYLEKTCEFLPDQGLVSECKEIVDSYLPVIMDMIKEELDKPEVVCSALALCQSLQKHLATMKLQKQLQTNKIPELDFSELASPFMANVPLLLYPQDKPKQKPKASGDVCQDCIQLVTDVQEAVKTNSSFVKSLVAHAKEECDRLGPGMSDMCKTYISEYSDLAIQMMMHMQPKDICAMVGFCASVKSVPLQPLVPAQVVHEVKMETVEKASVQEKASVQEKTFSLCEICETMVKEVTGLLESNKTEEEIVHEMEVVCRLFPGSVKDQCKDFIEVYGQAVIDMLLEATNPEAVCVMLKCCAANKLPQQPVVVKPAGGFCDICKMVVAYADKELEKNATTAEIEALLEKVCHFLPESVSDQCVQFVEQYEPVVVQLLAEVMDPTFVCTKLGVCESAKQPLLGDNACVWGPGYWCKNMDTAAQCNAVDHCKRHVWN","proteome":"UP000504624","gene":"LOC108502762","go_terms":[{"identifier":"GO:0006629","name":"lipid metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006665","name":"sphingolipid metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005764","name":"lysosome","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"5284db2b0b891bdcd45b15502e475cfcf2808b7e","counters":{"domain_architectures":793,"entries":20,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"profile":2,"smart":2,"cathgene3d":1,"ssf":1,"pfam":3,"pirsf":1,"panther":1,"prints":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":793}}}