{"metadata":{"accession":"A0A6I9PJX5","id":"A0A6I9PJX5_9TELE","source_organism":{"taxId":"8208","scientificName":"Notothenia coriiceps","fullName":"Notothenia coriiceps (black rockcod)"},"name":"18S rRNA (guanine-N(7))-methyltransferase","description":["S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro"],"length":282,"sequence":"MTSNCRRPEHTAPPDLFYNEVEAKKYSQNSRMIEIQTQMSERAVELLNLPEGQPCFLLDVGCGSGLSGDFLSEEGHYWVGVDISTAMLDVALDREVEGDLLVGDMGHGMPFRPGTFDGCISISALQWLCNADKRSHSPPKRLYTFFSTLYSSLSRGSRAIFQLYPENSEQLELITTQAMRAGFGGGMVVDYPNSSKAKKFFLCLFAGVTGSLPKGLGTETSDRAVSNQVQYSGQRCRFKGMKGKSAKKGRDWILEKKERRRRQGREVRADTKYTARQRKPNF","proteome":"UP000504611","gene":"bud23","go_terms":[{"identifier":"GO:0008757","name":"S-adenosylmethionine-dependent methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016435","name":"rRNA (guanine) methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0070476","name":"rRNA (guanine-N7)-methylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"ed1d41360c6cd8cff9c162bf3e76118dd104edb4","counters":{"domain_architectures":3185,"entries":10,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"cdd":1,"pfam":2,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":3185}}}