{"metadata":{"accession":"A0A6I9MKF6","id":"A0A6I9MKF6_9TELE","source_organism":{"taxId":"8208","scientificName":"Notothenia coriiceps","fullName":"Notothenia coriiceps (black rockcod)"},"name":"Transcription factor Spi-C","description":["Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression"],"length":270,"sequence":"MLADLETMAYVTEIRLSAGRGAWSAAPPSSCPEVDLEVIEEYLQEHSMEVHPAHTTASPPATVSPHTHVHPHQGTRITVNSWSGKHPYEWHSHTPHEEYDEQALHPAWPSPHDNQWDHIPYSYGAPGYFDSDSLSSGSQYQEYQDSPSPLSDRGGGIERDLLPLAPLSGKRKERLFQFLFEMLQTPSMRSCIWWVQSSSGTFQFSSENKERLAQLWGKRKGNRKTMTYQKMARALRNYSRTGEIKKVKRKLTYRFDEKTLRGLQGDSHSV","proteome":"UP000504611","gene":"LOC104941552","go_terms":[{"identifier":"GO:0003700","name":"DNA-binding transcription factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043565","name":"sequence-specific DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006357","name":"regulation of transcription by RNA polymerase II","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"9be233735550f087463761b543470356402b2953","counters":{"domain_architectures":13775,"entries":12,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"smart":1,"pfam":1,"profile":1,"panther":1,"prints":1,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":13775}}}