{"metadata":{"accession":"A0A6I8RRB6","id":"A0A6I8RRB6_XENTR","source_organism":{"taxId":"8364","scientificName":"Xenopus tropicalis","fullName":"Xenopus tropicalis (Western clawed frog)"},"name":"Glutamate receptor","description":["Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures. Functions in dorsal root ganglion neurons","Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist","Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system"],"length":889,"sequence":"MRSPNRLPHLGISHLEGPTGQLVSAEEQAFRFSASIINRNRTLLPNTTLTYDIQRINLYDSFEANRKACDQLALGVVAIFGPSHSSSSNAVQSICNALEVPHIQVRWKHHPLDNRDSFYVNLYPDYASLSHAILDLVQFLKWRSATVVYDDSTGLIRLQELIMAPARYNIRLKIRQLPPESEDARPLLKEMKRGREFRIIFDCSHTMAAQILRQAMAMGMMTEYYHYIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPYVSSIVDKWSMERHQATPKPESGLLDGIMTTDAALTYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGSRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGTWNPSDGLNITETARGRGPNISESLTNRTLIVTTVLEEPYVMFKRSDTPLFGKDRFEGFCIDLLKKIAEILGFDYDIRLVEDAKYGSQDEKGQWNGLVKELIDHKADLAVAPLTITHVREKVIDFSKPFMTLGISILYRKANGTAPSVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYDAHPCNPGTDVVENNFTLLNSFWFAVGALMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESAIDSADDLAKQTKIEYGAVVDGATMNFFKKSHISTFEKMWAFMSSRPSALVKSNEEGIQRVLSADYALLMESTAIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDRISIAILQLQEADEIHKMKERWWRSGGCPEEKNKEASALGIQNMGGIFIVLAGGLILSVVVAMAEFVYKLRKTAEREQRSFCSTMADEIRLSLTCQRRVKHKPQPPVMVKSDAVINMHTFNDRRLPGKDNMTCNTGLTPVFP","proteome":null,"gene":"grik3","go_terms":[{"identifier":"GO:0015276","name":"ligand-gated monoatomic ion channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005216","name":"monoatomic ion channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0038023","name":"signaling receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006811","name":"monoatomic ion transport","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"5be5a75d8df7f532ccd193e3dc07978378ca7a85","counters":{"domain_architectures":33948,"entries":19,"isoforms":0,"proteomes":0,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"ssf":2,"pfam":3,"cathgene3d":3,"smart":2,"panther":1,"prints":1,"interpro":6},"proteome":0,"taxonomy":1,"similar_proteins":33948}}}