{"metadata":{"accession":"A0A6I8QMH9","id":"A0A6I8QMH9_XENTR","source_organism":{"taxId":"8364","scientificName":"Xenopus tropicalis","fullName":"Xenopus tropicalis (Western clawed frog)"},"name":"Eukaryotic elongation factor 2 kinase","description":["Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced"],"length":735,"sequence":"MADEDLIFNMEGLDNIDLAKDRCSDYNKADSDEEDNFYICPITDDPAAQHQTKKKSPCFFTNLVKKTEYGTSSSPRNSFKNGHSKYSKHGCLAERGREAWKHAIQKAKQMPDPWAEFHLEDIETEHAIRHRYNAVSGQWVQDDVLIKMASQAFGRGAMRECYRTKKLSNFSHKQQWKSAYNYVSKRYLETVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIEMKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDVQGVGDLYTDPQIHTESGTDFGDGNLGVRGMALFFHSHACNRICKSMGLTPFDISAKEKAVLDNCSKMLQTAQTVVRGIEEKCGSNRVRTMSGSRPPLLSRLSENSGDDMSDMAFDSLPSSPSPVTPHGHRFDSHGWPIFNEVDNLLNEENNNLDNHRDSENGGDSGCPSEKRSESDELEHRIHNVGRRRFESESEDSFGKVSVEKWNQFHASRVHVHRPSCVAFEVERLNALELEKKIGKSILGKVHLAMVRYHEGGRFCEKDQEWDQESAIFHLEHAAHCGELEAIIGLGLMYSQSPHHILTDVSVQDTEDNRIKGFNYLLMAAEAGDRPSMIHVARAFDTGVNLGSDRIKDWQEALFWYDSALNMTDYDEGGEYDGTQDEPKYLLLAREAEMLLTGGFNLQKDPQRSGDLYTEAAEAAMEAMKGRLANQYYQKAEEAWACMEE","proteome":"UP000008143","gene":"eef2k","go_terms":[{"identifier":"GO:0004686","name":"elongation factor-2 kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004674","name":"protein serine/threonine kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005516","name":"calmodulin binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"19ee2e8562c742906acb41135171db33a726af8a","counters":{"domain_architectures":7574,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cdd":1,"cathgene3d":3,"profile":1,"smart":1,"pirsf":1,"panther":1,"pfam":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":7574}}}