{"metadata":{"accession":"A0A6I8PAH9","id":"A0A6I8PAH9_ORNAN","source_organism":{"taxId":"9258","scientificName":"Ornithorhynchus anatinus","fullName":"Ornithorhynchus anatinus (Duckbill platypus)"},"name":"Iron-sulfur cluster assembly enzyme ISCU","description":["Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex"],"length":159,"sequence":"MAGCAGLRFWASCFRSSPARLYHKKVVDHYENPRNVGSLDKTAKNVGTGLVGAPACGDVMRLQIQVDEKGKIVEARFKTFGCGSAIASSSLATEWVKGKTVDEALTIKNTDIAKELCLPPVKLHCSMLAEDAIKAALADYKLKQDPKKGGEAEEKPPSA","proteome":"UP000002279","gene":"ISCU","go_terms":[{"identifier":"GO:0005506","name":"iron ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051536","name":"iron-sulfur cluster binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016226","name":"iron-sulfur cluster assembly","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"1a14465eba7d2532ef70113b6acb6327d7aa9427","counters":{"domain_architectures":26938,"entries":8,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"ssf":1,"cathgene3d":1,"panther":1,"pfam":1,"ncbifam":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":26938}}}