{"metadata":{"accession":"A0A6I8NCQ0","id":"A0A6I8NCQ0_ORNAN","source_organism":{"taxId":"9258","scientificName":"Ornithorhynchus anatinus","fullName":"Ornithorhynchus anatinus (Duckbill platypus)"},"name":"Solute carrier family 12 member 3","description":["Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1"],"length":848,"sequence":"GTPSLNPSFTDEVPEGPVSRPRPPPEPTGERAGGEASRGRPEMAELPVSEMPGDPAHCSGRFTISTLLGSEDCAKGHSAHQAEPPSAVSDACHPSHLTHSNTFYMRTFGYNTIDVVPAYEHYANSQLPGEVKKGRPTLADLHSFLKVKAKPRGPRLTHEGRPGRGRGAEPVRFGWVKGVMVRCMLNIWGVILYLRLPWITAQAGIALTWVIVLLSVTVTTITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVAVAMHTVGFAETVRDLLQEYGSPIVDPTNDIRIIGVVTVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYFVGTLIPPSEEKAAKGFFSYRADIFAQNFVPNWRGAEGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTVSYLGAAGPDCFPAGSCVVRDASGGLNDTVPPGSPDCEGLACGYGWNFTQCMQGQNCHYGLSNYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNNEPIRGYLLAYAIAVGFILIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAVISVVIMFLLTWWAALIAIAIVIFLLGYVLYKKPEVNWGSSVQAGSYNMALNYSVGLNEVEEHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGNVLIGPRKQKMPELRLSSNGHTKWLNKRRIKSFYTDVIAEDFRSGVQILMQASGLGRMKPNILVIGYKRNWQSAHPGSATVWFPVGEDLTGPVPGCGEREREGERGTAGYRRVAGGWGERGDWAMEVEKNTE","proteome":"UP000002279","gene":"SLC12A3","go_terms":[{"identifier":"GO:0055085","name":"transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0015377","name":"chloride:monoatomic cation symporter activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006811","name":"monoatomic ion transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0022857","name":"transmembrane transporter activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"652155dec0773518079871907e2f820128aaeb01","counters":{"domain_architectures":2660,"entries":12,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pfam":3,"ncbifam":1,"panther":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":2660}}}